Popularity of Agmatine

In the past few years very few supplements have gained as much popularity or garnered as much attention from the sports supplement industry as agmatine. Although the name or mechanism of action may not be familiar to most, the majority of experienced athletes have had a long standing love/hate relationship with agmatine’s parent compound l-arginine.

Agmatine is a derivative of the conditionally essential amino acid l-arginine. It’s synthesized from l-arginine by a process known as decarboxylation which simply means that the carbolic acid group attached to end of l-arginine is cleaved off. Once the carbolic acid group is removed an agmatine metabolite is left over and then stored in neurons until it is activated by a stimulus such as training.

Agmatine has been called the “holy grail” of supplements due to its ability to affect a myriad of metabolic processes such as modulating nitric oxide synthase, boosting insulin sensitivity, enhancing cognitive function, reducing blood pressure regulation, and has even been shown to help reduce pain.

Skin Splitting Muscle Pumps

Most athletes and casual gym goers who use supplements are aware of nitric oxide and its ability to give new users euphoric skin splitting muscle pumps that they’ve never experienced before. However, the problem most users face is that the preworkout supplement that initially had given them an extra kick no longer seems to work, and those skin splitting muscle pumps begin fade. This is due in part to a built in regulatory mechanism produced by the body known as nitric oxide synthases.

In the body nitric oxide synthases are responsible for the synthesis of nitric oxide from arginine. When high levels of nitric oxide are continually present, like when the body is flooded with l-arginine from a new preworkout supplement, levels of certain nitric oxide synthases increase over time which can cause l-arginine based supplements to become less effective as the body compensates for the elevated levels of nitric oxide in the blood.

As previously mentioned agmatine is a metabolite of the amino acid l-arginine, and evidence has shown that agmatine has the ability to inhibit the production of some types of nitric oxide synthases which will help promote skin bursting pumps in each and every workout without quickly fading like nitric oxide supplements of the past.

Improved Insulin Sensitivity

Anyone looking to change the composition of their physique needs to understand the importance of controlling one of the most powerful hormones in the body; insulin. The ability use insulin more efficiently, and thus more effectively controlling blood glucose levels, is critical for optimizing the body’s muscle building and fat burning mechanisms.

A 2009 study published in the journal Neuroscience Letters found that supplementing with 1 mg doses of agmatine had the ability to improve insulin sensitivity and enhance glucose uptake into muscle cells with or without exercise in a four week clinical trial. Regular supplementation with agmatine could potentially lead to dramatic body recomposition due to its ability to positively impact blood glucose levels independent of exercise.

Nootropic Effects

Taking your physical performance to the highest level means that you’re going to have to bust through mental plateaus along the way. Even the most disciplined and well dedicated athletes encounter mental resistance that can derail their progress. Evidence shows that agmatine has the ability to improve mood and cognitive functions in a variety of ways including enhanced catecholamine release.

Catecholamine’s like dopamine, norepinephrine, and epinephrine (adrenaline) are released in response to external stresses like training. Dopamine is sometimes referred to as the “feel good” hormone, and is in part responsible for the euphoric feeling that athletes report after training and competition.

Reports indicate that agmatine has the ability to induce catecholamine release which can help provide the extra mental edge needed to push past physical barriers that have prevented you from achieving your full potential.

Conclusion

Agmatine is a unique supplement capable of providing enormous benefits to anyone looking to improve their mental and physical performance. Not only is agmatine proven to be effective in a clinical setting, but in the gym users have reported significant boosts in performance and physique composition as well. If you’re looking to take advantage of the wide spectrum of benefits that agmatine has to offer be sure to try potent hematogenic mass enhancing post-workout formula Adenoflex by GAT. Adenoflex is loaded with muscle building, pump enhancing, ingredients like agmatine that will help you elevate your performance to the next level.